Condition Info - BotMed Application

ConditionName

Primary Biliary Cholangitis (PBC)

ConditionDescription

Symptoms

Early symptoms:
Fatigue;
Itching;

Later symptoms:
Pruritus;
Dermographism;
Steatorrhea;
Dry eyes and mouth;
Pain in the upper right abdomen;
Bone, muscle or joint (musculoskeletal) pain;
Weight loss;

PhysicalFindings

Hyperpigmentation d/t melanin deposition;
Splenomegaly;
Edema;
Ascites;
Jaundice;

ClinicalTests

Bilirubin normal;
↑ALP;
↑cholesterol;
Antimitochondrial antibodies (AMAs) (sensitive and specific);
Most accurate: LV biopsy;

RiskFactors

Female 40-50;
Autoimmune;

IsRedFlag

IsNPLEX

Consequence

Xanthelasma/xanthoma;
Osteoporosis;
Malabsorption;
Fractures; 
Hypothyroidism;

ProgressionFromCondition

TreatmentOptions

Liver transplant;

PharmOptions

WebLink

https://www.merckmanuals.com/en-ca/professional/hepatic-and-biliary-disorders/fibrosis-and-cirrhosis/primary-biliary-cholangitis-pbc