Condition Info - BotMed Application

ConditionName

Sjögren Syndrome

ConditionDescription

Idiopathic autoimmune disorder secondary to Abs predominantly against lacrimal and salivary glands

Symptoms

Dry eyes;
Dry mouth;
Joint pain, swelling and stiffness;
Swollen salivary glands;
Skin rashes or dry skin;
Vaginal dryness;
Persistent dry cough;
Prolonged fatigue;

PhysicalFindings

ClinicalTests

Schirmer test – best initial test

Most accurate test: lip or parotid gland biopsy;

Best initial blood test: SS-A and SS-B Abs (not specific, also positive in SLE);

Positive anti-Ro AB;
Positive anti-La AB;

(+ANA);
RF;
Anemia;
Leukopenia;
Eosinophilia;

RiskFactors

Female;

Associated with:
RA;
SLE;
Primary biliary cirrhosis;
Polymyositis;
Hashimoto thyroiditis;

IsRedFlag

IsNPLEX

Consequence

Secondary Raynaud Syndrome;

Dental problems -> loos of teeth;

Lymphoma – most dangerous complication – 10%;

ProgressionFromCondition

RA;
Primary biliary cirrhosis;
SLE;
Lymphoma;

TreatmentOptions

NO CURE!

PharmOptions

Best initial therapy: drink water frequently, small sips!
Sugar-free gums;

Eye drops: artificial tears to avoid corneal ulcers;

Pilocarpine – stimulate production of saliva;
Corticosteroids;

WebLink

https://www.merckmanuals.com/en-ca/professional/musculoskeletal-and-connective-tissue-disorders/autoimmune-rheumatic-disorders/sjögren-syndrome