Condition Info - BotMed Application

ConditionName

Angioedema

ConditionDescription

Sudden swelling of face, tongue, eyes, airway. Angioedema often idiopathic.

Symptoms

Welts that form in minutes to hours.
Swelling and redness, especially around the eyes, cheeks or lips.
Pain or warmth in the affected areas.
Hereditary: no itching, purities;

PhysicalFindings

ClinicalTests

Clinical evaluation.
Best initial test:
C2 and C4 in complimentary pathway -> decreased;
C1 esterase inhibitor -> decreased;

RiskFactors

Family history;
Recent start of ACE inhibitors;
Can be from deficiency of C1 esterase inhibitor;
Onset can be associated even with minor trauma;

Allergic angioedema (this is the most common kind):
Shellfish;
Fish;
Peanuts;
Tree nuts;
Eggs;
Milk;
Pollen;
Animal dander;
Latex;
Insect stings;

IsRedFlag

IsNPLEX

Consequence

ProgressionFromCondition

Anxiety or stress;
Minor infections;
High or low temperatures;
Overdoing it when you exercise;

Acquired: trauma;

3types of hereditary:
Type 1 – decreased level of C1NH(85%)
Type 2 – normal level but decrease function C1NH(15%)
Type 3 – no detected abnormality in C1NH

Drugs caused:
Penicillin;
Aspirin;
NSAIDs (ibuprofen, naproxen);
ACE inhibitors;

TreatmentOptions

Airway: ensure airway protected first!
Stay away from allergens;

PharmOptions

For hereditary steroids do not work!
If necessary remove ACE inhibitors or other medications;

WebLink

https://www.merckmanuals.com/en-ca/professional/immunology-allergic-disorders/allergic,-autoimmune,-and-other-hypersensitivity-disorders/angioedema