Condition Info - BotMed Application

ConditionName

Myasthenia Gravis

ConditionDescription

Symptoms

Double vision, difficulty with chewing;

Weakness of limb muscles worse at end of the day;

Ptosis, diplopia (50%);

Worse with exercises! 

Dysarthria (difficulty to speak);
Dysphagia (difficulty swallowing);

PhysicalFindings

DTR – normal;
Sensory – normal;
Motor weakness;
Normal pupillary responses!

ClinicalTests

Ach receptors Abs (80-90% sensitivity);

Most accurate test: electromyography (EMG)– show decreased strength with repetitive stimulation;

Chest xRay, CT, MRI (thymoma or thymic hyperplasia);

RiskFactors

Associated with:
Thymoma;
Thymus neoplasm;
Thyrotoxicosis;

Young age, female;

IsRedFlag

IsNPLEX

Consequence

Severe MG affects respiratory muscles;

ProgressionFromCondition

TreatmentOptions

If drugs do not help: surgery;
Thymectomy (60-80% effective) for <60 y/o;

PharmOptions

>60 y/o;
IVIG or plasmapheresis;

Prednisone;

WebLink

https://www.merckmanuals.com/en-ca/professional/neurologic-disorders/peripheral-nervous-system-and-motor-unit-disorders/myasthenia-gravis