Condition Info - BotMed Application

ConditionName

Primary Hyperaldosteronism (Conn's disease)

ConditionDescription

High aldosterone levels lead to salt and water retention and potassium wasting.

Symptoms

Muscle cramps;
Weakness/dizziness;
Fatigue;
Headache; 
Blurred vision;
A frequent need to urinate, nocturnal;
Excessive thirst;

PhysicalFindings

↑BP - Hypertension (secondary);
No pitting edema;

ClinicalTests

↓renin;
↓ K;
Best initial: renin/aldosterone ratio (ratio > 20-30 - positive test);

CT or MRI – only after lab work!
Most accurate: adrenal venous blood sample;
PAC:PRA;
High:Low;

RiskFactors

IsRedFlag

IsNPLEX

Consequence

Patient with HPT on 2 meds

ProgressionFromCondition

Solitary adenoma (80-85%)
Hyperplasia  15-20%
Cancer 1%

TreatmentOptions

Surgery laparoscopy (unilateral)

PharmOptions

Spironolactone (bilateral) – aldosterone antagonism AE: gynecomastia, ED, anti-androgenic

WebLink

https://www.merckmanuals.com/en-ca/professional/endocrine-and-metabolic-disorders/adrenal-disorders/primary-aldosteronism