Condition Info - BotMed Application

ConditionName

Peptic ulcer disease (PUD)

ConditionDescription

Symptoms

70% - not symptomatic;

Epigastric pain or discomfort;
Duodenal ulcer: pain relieved with food after 30+min; weight gain;
Gastric ulcer: pain exacerbated by food; weight loss;
Signs of GI bleed: Melena, Anemia;
History of NSAID intake;

PhysicalFindings

ClinicalTests

Anemia, positive FOBT (in cases of bleeding ulcer);
Most accurate: Urea breath test for H. pylori: positive in most cases of PUD;
H.Pylori: (90% of duad and 70% of gastric);
EGD(Esophagogastroduodenoscopy): Mucosal erosions and/or ulcers are required for a definitive diagnosis.

RiskFactors

H.pylori;
NSAIDs use;
Smoking;
Alcohol;
Age;
Steroids use;
Hypercalcemia (may stimulate acid production);

Stress induced ulcers;
Radiation;
Surgery;
Chemo;
CMV;

IsRedFlag

IsNPLEX

Consequence

Anemia;
Dysphagia;
Weight loss;
Cancer;

ProgressionFromCondition

TreatmentOptions

Treatment failure b/c: Alcohol, tobacco, usage of NSAIDs

PharmOptions

PPI, misoprostol;
Clarithromycin, Amoxicillin (metronidazole with penicillin allergy);
Bismuth for treatment resistant ulcer;

WebLink

https://www.merckmanuals.com/en-ca/professional/gastrointestinal-disorders/gastritis-and-peptic-ulcer-disease/peptic-ulcer-disease