Condition Info - BotMed Application

ConditionName

Polyarteritis nodosa (PAN)

ConditionDescription

Systemic vasculitis of small and medium-sized arteries. Necrotizing inflammation of medium or small arteries without glomerulonephritis or vasculitis in arterioles, capillaries, or venules

Symptoms

Very nor specific!
Petechiae; purpura; ulcers; livedo reticularis; nodules; 
Generalized abdominal pain worsen by eating: mucosal bleeding; nausea; vomiting; 
Symptoms depend on location and severity of the arteritis and extent of secondary ischemia; 
Only one organ or organ system may be affected; 
General symptoms: fever; fatigue; night sweats; loss of appetite; weight loss; and generalized weakness; 
History Hepatitis B or C (20%);
Spear lungs!

PhysicalFindings

Peripheral neuropathy any large nerve can be involved (foot drop)

ClinicalTests

Most appropriate test: Hep B surface antigen;

Most accurate: biopsy of affected site;

Blood test:
Anemia, leukocytosis;
↑ESR, CRP;

P-ANCA – negative, only 20% positive;

Angiography: renal, mesenteric, hepatic artery – aneurysmal dilation;
Biopsy: most accurate for renal dz;

RiskFactors

Association with Hepatitis B and C;

IsRedFlag

IsNPLEX

Consequence

Stroke, MI, particularly in young;

Rare: gangrene;

ProgressionFromCondition

TreatmentOptions

PharmOptions

Prednisone reduce mortality

WebLink

https://www.merckmanuals.com/professional/musculoskeletal-and-connective-tissue-disorders/vasculitis/polyarteritis-nodosa-pan