Condition Info - BotMed Application

ConditionName

Hepatitis B

ConditionDescription

Symptoms

Malaise, arthralgias, fatigue
Nausea/Vomiting
RUQ pain
Jaundice, scleral icterus
Hepatomegaly, splenomegaly, lymphadenopathy

PhysicalFindings

ClinicalTests

Hep B DNA PCR – best for determine viral replication activity

↑AST ↑ALT
↑ALP 
↑bilirubin


Test:
IgM – acute
IgG – chronic 

sAg(+), eAg(+) – acute, 90% pass Dz to the child
sAg(+), eAg(-) – acute, 10% pass Dz to the child
CoreAb(+), sAb(+) – chronic, cured
sAb(+) ONLY! - vaccine

RiskFactors

Any needle injury
Sexual contacts
Men with men sex contacts
IV drug use
Alcoholism
Travel to developing country
Poor sanitation

IsRedFlag

IsNPLEX

Consequence

Cirrhosis
Liver cancer
Polyarthritis nodosa – typical for hep B

5% adults and 90% of children will develop chronic hep b may lead to cirrhosis;
Hepatocellular carcinoma;

Persistent carrier state;

Extrahepatic manifestations: 
Polyarteritis nodosa (KI damage);
Glomerulonephritis (adults >children);

ProgressionFromCondition

TreatmentOptions

PharmOptions

Interferon alpha
hep B vaccine

WebLink

https://www.merckmanuals.com/professional/hepatic-and-biliary-disorders/hepatitis/hepatitis-b,-acute