Condition Info - BotMed Application

ConditionName

Immunoglobulin A–Associated Vasculitis (IgAV, Henoch-Schonlein purpura)

ConditionDescription

Small vessel vasculitis. Systematic deposition of IgA in different tissue
Immunoglobulin A–dominant immune deposits, affecting capillaries, venules, or arterioles; typically involves skin, gut, and glomeruli; associated with arthralgias or arthritis

Symptoms

Generalized abdominal pain; bleeding; 
Skin: purpura – from the buttocks down 
Joint: arthralgia (low extremities, large joints) 
Renal: hematuria 

Leukoclastic reaction: painless, palpable purpura of buttocks and legs;

PhysicalFindings

Clinical diagnosis; Palpable rush;

ClinicalTests

Clinical diagnosis.
UA – microscopic hematuria (not specific), proteinuria 
PT, PTT;
PLATELETS ARE NORNAL;

Biopsy – most accurate test but never done (leukocytoclastic vasculitis);

RiskFactors

Children 2-8 years/old;
Boys;
African-Americans;

IsRedFlag

IsNPLEX

Consequence

Renal insufficiency is not reversible;
Nephritic, nephrotic syndrome;

ProgressionFromCondition

Usually follow URI;

TreatmentOptions

Most cases self-limited

PharmOptions

Supportive care (water, NSAIDs);
Steroids – severe cases associated with progressive renal insufficiency;

WebLink

https://www.merckmanuals.com/professional/musculoskeletal-and-connective-tissue-disorders/vasculitis/immunoglobulin-a–associated-vasculitis-igav