Condition Info - BotMed Application

ConditionName

Addison disease

ConditionDescription

Progressive hypofunctioning of the adrenal cortex.

Symptoms

Fatigue;
Light headedness;
Weakness;
Fever;
Weight loss;
Anxiety;
Darkening palmar creases (chronic adrenal insufficiency - primary);

Addisonian crisis:
Sudden loss of strength; 
Severe pain in the lower back, abdomen or legs; 
Vomiting and diarrhea potentially causing dehydration; 
Low blood pressure and loss of consciousness.

PhysicalFindings

Low BP;

ClinicalTests

↑ACTH; ↓Cortisol.

ACTH stimulation test:
↑Cortisol (primary);
↓Cortisol (secondary and tertiary);

↓Na;
↑K;
Metabolic alkalosis;
Hypoglycemia;

RiskFactors

IsRedFlag

IsNPLEX

Consequence

Hypotension;
Hyperkalemia;
Low BP b/c hemorrhage, surgery, trauma, sudden stop of high dose prednisone;
↑BUN;
Eosinophilia

ProgressionFromCondition

Adrenocortical Insufficiency.
Autoimmune (80%);
Infection TB;
Cancer of adrenals (metastatic);
Chronic corticosteroids use.

TreatmentOptions

Treat underlining cause;
Hydration;
Adding cortisol during stress: surgery, infection

PharmOptions

Glucocorticoid (hydrocortisone);
Mineralocorticoid

WebLink

https://www.merckmanuals.com/en-ca/professional/endocrine-and-metabolic-disorders/adrenal-disorders/addison-disease